After Chancellor’s last seizure, I posted this question to a great yahoo group for dogs with seizures K9 Epileptics: I’ve noticed a pattern over the past 3 – one being springtime and the other happening after the last Keppra of the night. I’m thinking I need to increase the evening dosage. Has anyone noticed this in their dogs? We just had levels done and hypothyroid pill increased by 1/2 tablet to 7 per day and Keppra levels were good. Waiting on the kBr at the moment.
Noticing patterns are so important and taking a proactive stance on treatment of your dog is vital. The answers I received were wonderfully revealing (the difference you’ll see is Chancellor is NOT on PB (phenobarbitol) but IS ON kBr (potassium bromide). The references to half life differences if a dog is on PB vs. kBr were interesting to note.
Answer from list leader Alexandra: Technically, there is not a scientifically determined ‘range’ for dogs (in Keppra),so they (veterinarians) are going by human values. I am not sure if human ranges are the same for therapeutic ranges in dogs (for PB?) but it is what we all are going off of. Is Chancellor on PB? From Plumb’s vet manual for Keppra – the half life in a dog for Keppra while on PB (I would need to re-read to be precise) is ~1.73 hours (half of the half life without PB). I dose 4 times a day, but even that would fall short on coverage. I am not sure how often you dose, but you might consider giving an extra dose at bedtime. We give meds (Keppra) at 11pm, then again at 5-6am (Keppra). Could be that the Kbr needs adjusting.
This was my gut feeling in watching Chancellor’s behavior and will be a consideration after some more research.
Another post was equally as interesting and certainly food for thought.
By Lynne: I routinely up PB from 105mg BID to 120mg BID when the
temperatures get above 80 degrees (F) for more than a week. If he gets
twitchy, his evening PB will be increased another 15mg. Once the
temperatures back down to the 70s and below, we’ll drop his dose back down.
We’ve been doing this for about three years now.
NOTE: Chancellor’s last seizure was during the BIG full moon, a time when temperatures do change and even other unexplained phenomena may be occurring. Shows how sensitive dogs are to their surrounding environment, weather, atmospheric changes.
These are considerations veterinarians need to take more seriously when treating a dog with seizures and provide proper protocols for dog owners.